Channel 5 confirmed Friday morning that it had axed Big Brother and Celebrity Big Brother after seven years. The show started on the channel in 2011 after a decade on Channel 4, but won't be back after 2018.
The latest series - which begins tonight at 9PM - will be the last ever.
Channel 5 said today: "The forthcoming series of Big Brother will be the last - of either celebrity or civilian versions - on Channel 5. We’d like to thank Endemol and all of the production team who have worked tirelessly to make the show a success."
Although Big Brother won't be back on Channel 5, there's potential for another channel switch like in 2011.
There were previously rumours that the show could even move online to a streaming service such as Netflix.
Production company Endemol said in a statement that Big Brother "continues to be a global phenomenon" with series in 20 countries, including the US which recently launched its first ever Celebrity season.
They added: "Whilst disappointed not to reach an agreement with Channel 5 the decision opens up a new chapter and we are excited about future possibilities for Big Brother in the UK."
Bit On The Side's Rylan Clark-Neal said before today: "It's a massive part of my life and I know it can be even better with the right TLC. I'd do everything in my power to make sure CBB and the civilian BB are still on the air."
He vowed: "I will fight to the death to make sure it never goes away. If I had the money and owned the channel, I would buy the programme and film it in my garden."
Meanwhile, host Emma Willis has spoken out on the show's axe.
She said: "The news was a shock, if I'm honest but I kind of still hold out hope that somebody out there loves it as much as we do and gives it a home in the future because it has been on the TV for a bloody long time and you know, it's part of our popular culture.
"So it would be sad. It would be sad to see its end."
Emma hinted: "It'd be lovely to see it come back for its 20th anniversary!"
Rylan added of Big Brother's goodbye: "I hope one day Big Brother will return but my focus now, as with the rest of the team is to make our last series the best yet.
"I'd like to thank all of our guests, housemates and teams from over the years, Endemol and Channel 5 for having me and most of all the viewers for sharing this amazing journey. I learned how to host a show on the job here and I'll be forever grateful for the opportunity. R x"
For now, the last ever series on Channel 5 airs Saturday-Friday nights.