Sian Gibson and Johnny Vegas will star in brand series Murder They Hope on Gold.
The pair will reprise their roles as Gemma and Terry in Jason Cook's murder-mystery franchise.
The new three-part series follows previous instalments Murder on the Blackpool Express, Death on the Tyne and Dial M for Middlesbrough.
Joining the cast alongside Johnny Vegas and Sian Gibson are Sarah Hadland (Miranda) as Monica, Gemma's spotlight stealing sister, and Shobna Gulati (dinnerladies) as Gemma's sister-in-law and local police officer Vicky.
Also appearing throughout the series are Lee Mack (Not Going Out), Paul Whitehouse (The Fast Show), Hannah Waddingham (Sex Education), Kiell Smith-Bynoe (Ghosts), Adrian Scarborough (Gavin and Stacey), Jason Barnett (Bridgerton), Layton Williams (Bad Education), Nitin Ganatra (EastEnders), Steve Edge (Benidorm), Janine Duvitski (Benidorm) and comedian Jason Manford.
Murder They Hope will start on Saturday, 8 May on Gold.
Jason Cook said: "It's going to be amazing to be back with Terry and Gemma and this time for a series! Having multiple episodes has really let us go to town in creating a world of eccentric characters and big adventures for my favourite ex-Coach driving detectives!"
Teasing the new three-part series, Gold shared: "After their trip to Middlesbrough turned a little more explosive than they thought, Gemma (Sian Gibson) and Terry (Johnny Vegas) finally decide to pack up the smouldering remains of their coach tour business and set out on a new adventure as fully-fledged private detectives.
"Given all their experience with solving cases (sort of), that mysteriously fall into their laps the duo are confident that it won't be long before they get the chance to put their skills to the test. Sadly, the cases don't come rolling in and the duo find themselves moving in with Gemma's sister Monica and praying business picks up soon.
"Sure enough the first case that hops into their laps comes via a local car boot sale, where a mysterious red eyed rabbit figurine causes a bidding war and attracts the attention of the dreaded, but appropriately named, Bunnyman.
"Episode two sees Gemma and Terry heroically graduate from bunnies to bakers, when they are tasked with getting to the bottom of poisoned pastry scandal as two rival baking families turn up the heat on a long-standing feud.
"The final instalment of the trilogy sees the intrepid duo lured back into their old world of coach tours as they help the local police in a county-wide hunt for a bus-based serial killer."
Murder They Hope will air on Gold in 2021.
Gold is available on Sky 110/810, Virgin 124, BT & TalkTalk 310 +1: Sky 210, Virgin 190, TalkTalk 314 On demand on Sky, Virgin, BT, Now TV and TalkTalk.