Over 7 million viewers watched last Friday's episodes, which saw David Platt sexually assaulted by Josh Tucker.
Josh was seen spiking David's drink in dark scenes for the ITV soap.
The Sun newspaper reports that 122 people have made official objections to Ofcom over the storyline.
The TV watchdog said in a statement: "We would assess any complaints under our broadcasting rules, before deciding whether or not to investigate.”
Coronation Street boss Kate Oates defended her storyline last week: “We decided to cover the topic of male rape to help try and highlight the culture of silence that surrounds male sexual assault, and issues surrounding male mental health in general."
She added: "Survivors Manchester have been so generous with their time and knowledge, working with Jack, Ryan and the team, and I’m in awe of the work they do.
"Over the next few weeks of Corrie, our message is to talk: it’s hard to speak out, but if you’re suffering in silence, there are people out there willing to listen and support you."
A spokesperson for ITV said: "Coronation Street has a long and successful history of tackling serious and thought provoking issues alongside the balance of drama, romance and comedy that the soap is famous for.
"We are mindful of our transmission time and therefore the attack was implied rather than explicit, there was also a warning issued before the episode and info about how to access help at the end.
"Subsequent episodes will focus on David's mental health as he keeps what has happened to him a secret and struggles to come to terms with the attack."
SurvivorsUK is a charity that offers help and support for male victims of rape and sexual assault.