The girls, who are about to release their new single Wings, told Capital FM this week that they would love to duet with the fellow X Factor stars.
One Direction didn't manage to win their series back in 2010, but have gone on to become one of the show's biggest successes, with their debut album topping charts across the world.
Little Mix's Leigh-Anne Pinnock commented the group would love to sing with the boys.
“I think it would be really interesting, a Little Mix and One Direction [song]," she told the radio station. "Imagine what that would be like.”
Meanwhile Little Mix's Perrie Edwards - who is dating One Direction's Zayn Mailk - revealed that they had heard some of One Direction's new material.
“I heard one [song]," she said. "We heard a cheeky little song, but we’re not allowed to say anything. It’s brilliant. The fans will love it.”
The boys are set to release their new album before Christmas, along with Little Mix, which could cause some arguments between the groups!