The trio of feisty X Factor females will take to the stage at the annual outdoor event at Weston-Super-Mare in July.
Tulisa will be performing material from her debut solo album, with debut single Young set for release later this month.
Little Mix meanwhile are also set to perform new material at the event, with a release for their new single slated for this summer.
Also amongst the acts announced so far are Olly Murs' pals Rizzle Kicks and rapper Wretch 32.
Syco's Labrinth will also join the line up, as well as Tulisa's former N-Dubz bandmate Dappy and Brit star Professor Green.
For more information and tickets, see the official T4OTB website.