Fountain Studios in Wembley has been home to The X Factor and Britain's Got Talent live shows for years, as well as having been used for filming of The Voice UK, All Star Mr & Mrs and The Cube.
Going back further, they were also where the Friends episode set in Britain was recorded in the 90s.
In January of this year it was confirmed that the studio owners had sold the building to property developers.
Now it's been revealed the location will be flattened to make way for flats after tonight's X Factor semi-final, making this evening's show the last ever to air from Fountain. The X Factor final will air live from the nearby Wembley Arena next weekend.
Both BGT and X Factor have aired their live shows from Fountain since their first series in 2007 and 2004 respectively while the studios themselves date all the way back to the 1920s.
Dermot O'Leary said: "I started here, I did my first ever pilot here when I was still a runner. I got a screen test and the pilot ended up being here.
"It was my first ever hosting job so it holds a great poignancy and big significance to me."
Richard Holloway, managing director of Thames who make The X Factor and BGT, said: "It's a sad day because it's a TV studio which is closing down and will not be replaced. Purpose built TV studios are difficult to find."
The news means that both Britain's Got Talent and X Factor will move to a new location for their lives shows next year.
For now, The X Factor continues tonight at 8PM on ITV.