According to C4, the format - which has the working title 'The Courtney Act Show' - is the "world's first Dragazine show".
It will see the glamorous RuPaul's Drag Race favourite chat to celebrity guests and present studio items and music numbers.
The broadcaster teased that "Courtney’s skill and sass will redefine late night television entertainment".
Bosses have ordered a one-off 60-minute special, with a series likely to follow if it proves successful.
Monkey Kingdom, the company behind Made In Chelsea, is producing.
Courtney said: "This is my show and I say come on in, all you heroic misfits, those of you who are a bit chipped around the edges… I want to welcome you all.
"You bring the open minds and I’ll bring the open bar and we’ll meet in the middle for a gay old time!"
Sarah Lazenby, C4's commissioning editor for entertainment, commented: "Courtney has undeniable star quality.
"As entertaining as she is emotionally intelligent, as savvy as she is sassy, Courtney was born to perform. We are utterly delighted she has chosen to come to the Channel to host the world’s first Dragazine show."
Monkey Kingdom's Ollie Brack added: "Courtney has a smart and sensitive take on the world, a super-quick wit, a killer voice and a wardrobe to match.
"We’re really excited to be working with her. Now is the perfect time for her show and Channel 4 is the perfect home for it."
A non-broadcast pilot was filmed in May, under the name 'Up Late and Courtney Act'.
Courtney started out auditioning for Australian Idol in 2003, before she rose to fame on the sixth season of RuPaul's Drag Race in 2014.
She reached the grand final, finishing as joint runner-up to Bianca Del Rio.
Following an appearance on MTV's celebrity dating show Single AF, Courtney joined Celebrity Big Brother in January.
After 32 days in the house, viewers crowned her the series champion, with 49.43% of the public vote.