Things kicked off in the middle of the night when a bored Jedward decided to fashion some pizza boxes into a 'robot' outfit.
But their disruptive behaviour when others were trying to sleep left Nicola in a rage.
"No one's f**king interested," she snapped. "You're just trying to stay in the house," she added ahead of tonight's eviction.
"My six-year-old is more intelligent and respectful than you. BYE!" Nicola ranted at Jedward in the bedroom. "You're such... honestly, you're six."
"You're six," repeated Nicola as Jedward continued to speak over her.
The next morning, the other housemates awoke to find the mess that Jedward had created while they had slept.
Referring to Nicola's outburst during the night, Stacy Francis remarked: "I don't blame her, it gets ridiculous."
Calum Best agreed: "It blows my mind you can be 25 and do things like that."
However Jedward defended their "revolutionary" pizza box outfit.
"Your behaviour is just bizarre," Nicola told the pair.
"We're bored out of our heads, what's the big deal?" Jedward asked.
"The big deal is when you're coming in the bedroom when people are asleep to show us pizza boxes. I think it's ridiculous," Nicola told the twins.
The pair's chat then escalated again as they began to row over who had started this latest argument.
"You're bringing it up," Jedward claimed.
"No you brought it up! You brought it up, I didn't bring anything up. Stop talking s**t!" Nicola concluded.
Celebrity Big Brother 2017 airs tonight on Channel 5 at 9PM.