A spokesperson for Channel 5 said in a statement: "Due to medical reasons, David Gest has decided to leave the Celebrity Big Brother House."
They added: "His exit will appear in tonight’s show on Channel 5 at 9pm."
Following David's decision to leave, Big Brother gathered up the housemates this morning to break the news.
To shocked reactions of 'Oh My God!', Big Brother told the group: "This is Big Brother, David has left the Big Brother house for medical reasons."
Big Brother added: "David wanted to let you all know that he loves you and he's sorry he is too sick to continue."
The group responded by shouting 'We love you, David' back.
Music producer and TV personality David has been ill inside the house for the past week.
On last night's latest highlights episode he was seen resting in Big Brother's spare bedroom away from the other housemates for the second time this series.
Tomorrow's latest eviction - which sees John Partridge, Kristina Rihanoff, Tiffany Pollard and Danniella Westbrrook - is expected to go ahead as planned as another celebrity is given the boot live on Channel 5 by Emma Willis.
You can catch the latest from the Celebrity Big Brother house, including David's exit on tonight's show at 9PM on Channel 5.
As always, stick with us for all the latest!
Watch a video of the housemates reactions to David's departure below...